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Mirmira, Raghu
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Concept Aconitate Hydratase
Concept Age Factors
Concept Eflornithine
Concept Arachidonate 5-Lipoxygenase
Concept Autophagy
Concept Cyclic AMP
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Concept Alloxan
Concept Amino Acid Isomerases
Concept Energy Intake
Concept Angiotensin-Converting Enzyme Inhibitors
Concept Analysis of Variance
Concept Antibodies, Monoclonal
Concept Arachidonate 12-Lipoxygenase
Concept Arachidonate 15-Lipoxygenase
Concept Base Sequence
Concept Diabetes Mellitus, Experimental
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Concept Dogs
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Concept Genes, Bacterial
Concept Fasting
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Concept Heptanes
Concept Escherichia coli
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Concept Interleukin-1
Concept Multigene Family
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Concept Mentors
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Concept Leukotriene B4
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Concept Mice, Transgenic
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Concept Random Allocation
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Concept Cricetinae
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Concept ROC Curve
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Concept Retina
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Concept Cluster Analysis
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Concept Lipoxygenase Inhibitors
Concept Tumor Necrosis Factor-alpha
Concept Practice Guidelines as Topic
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Concept Ganglia, Sensory
Concept Histocompatibility Antigens Class I
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Concept Th1 Cells
Concept Cell Culture Techniques
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Concept Reverse Transcriptase Polymerase Chain Reaction
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Concept Glucose Clamp Technique
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Concept Mutagenesis, Site-Directed
Concept Sequence Alignment
Concept Case-Control Studies
Concept RNA Interference
Concept Peer Review, Research
Concept Methylation
Concept Genes, Reporter
Concept National Institutes of Health (U.S.)
Concept Arachidonic Acid
Concept Interferon-alpha
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Concept CD8-Positive T-Lymphocytes
Concept Gene Expression Regulation, Developmental
Concept Cell Proliferation
Concept Pancreatic Polypeptide-Secreting Cells
Concept Thapsigargin
Concept Interleukin-12
Concept Apoptosis Regulatory Proteins
Concept Glucose Intolerance
Concept Hepatocyte Nuclear Factor 1-alpha
Concept Caspase 3
Concept Gene Regulatory Networks
Concept Metabolic Syndrome
Concept Gene Knockout Techniques
Concept Collagenases
Concept Reactive Oxygen Species
Concept Antiretroviral Therapy, Highly Active
Concept Collagen Type I
Concept Eukaryotic Initiation Factor-4E
Concept Primary Cell Culture
Concept Carboxypeptidase H
Concept Proteomics
Concept NIH 3T3 Cells
Concept Chromatin Assembly and Disassembly
Concept Hepatocyte Nuclear Factor 1
Concept Hepatocyte Nuclear Factor 3-alpha
Concept Chromatin Immunoprecipitation
Concept Mitogen-Activated Protein Kinase 14
Concept COS Cells
Concept Microscopy, Confocal
Concept Ribosomal Protein S6 Kinases
Concept Cyclin B
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Concept Transforming Growth Factor beta1
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Concept Interleukin-2 Receptor alpha Subunit
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Concept Adaptor Proteins, Signal Transducing
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Concept Insulin-Secreting Cells
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Concept Heart Transplantation
Concept Cyclins
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Concept Open Reading Frames
Concept Islets of Langerhans Transplantation
Concept Transfection
Concept Reproducibility of Results
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Concept Gene Expression Regulation, Enzymologic
Concept Polymerase Chain Reaction
Concept ATP-Binding Cassette Transporters
Concept CD3 Complex
Concept DNA Methylation
Concept Myeloid Differentiation Factor 88
Concept Dipeptidyl-Peptidase IV Inhibitors
Concept Gene Silencing
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Concept HSP90 Heat-Shock Proteins
Concept Anti-HIV Agents
Concept Histone Deacetylase Inhibitors
Concept Cyclin A
Concept Fibrillar Collagens
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Concept STAT1 Transcription Factor
Concept Hepatocyte Nuclear Factor 1-beta
Concept Transcriptome
Concept HLA-DQ beta-Chains
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Concept Insulin Receptor Substrate Proteins
Concept Hep G2 Cells
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Concept Multiplex Polymerase Chain Reaction
Concept Organogenesis
Concept GTP-Binding Protein alpha Subunits, Gq-G11
Concept Pancreas, Exocrine
Concept Cyclin D2
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Concept Th17 Cells
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Concept Mice, Inbred NOD
Concept Sequence Analysis, RNA
Concept Cyclic AMP-Dependent Protein Kinases
Concept Disease-Free Survival
Concept Genomics
Concept Tissue Engineering
Concept MicroRNAs
Concept Epigenesis, Genetic
Concept CARD Signaling Adaptor Proteins
Concept Sarcoplasmic Reticulum Calcium-Transporting ATPases
Concept TYK2 Kinase
Concept Growth Differentiation Factor 15
Academic Article Interactions of a hybrid insulin/insulin-like growth factor-I analog with chimeric insulin/type I insulin-like growth factor receptors.
Academic Article Analysis of serum Hsp90 as a potential biomarker of ß cell autoimmunity in type 1 diabetes.
Academic Article Corrigendum: IRS1 deficiency protects ß-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation.
Academic Article Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.
Academic Article Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.
Academic Article Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.
Academic Article Comparative analysis of diagnostic platforms for measurement of differentially methylated insulin DNA.
Academic Article Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.
Academic Article Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.
Academic Article The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.
Academic Article Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.
Academic Article Disposition of the phenylalanine B25 side chain during insulin-receptor and insulin-insulin interactions.
Academic Article A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo.
Academic Article Insights into mentorship for endocrinologists.
Academic Article Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains.
Academic Article Elevations in the Fasting Serum Proinsulin-to-C-Peptide Ratio Precede the Onset of Type 1 Diabetes.
Academic Article Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264.
Academic Article eIF5A inhibition influences T cell dynamics in the pancreatic microenvironment of the humanized mouse model of Type 1 Diabetes.
Academic Article 1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.
Academic Article Detection of islet ß-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.
Academic Article Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.
Academic Article In situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo.
Academic Article AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.
Academic Article Mouse and human islets survive and function after coating by biosilicification.
Academic Article Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
Academic Article Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.
Academic Article Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.
Academic Article Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet ß cells.
Academic Article Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
Academic Article Expression and function of Set7/9 in pancreatic islets.
Academic Article The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter.
Academic Article A system for detecting high impact-low frequency mutations in primary tumors and metastases.
Academic Article Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.
Academic Article The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.
Academic Article 12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.
Academic Article Translational control of inducible nitric oxide synthase by p38 MAPK in islet ß-cells.
Academic Article Elevated unmethylated and methylated insulin DNA are unique markers of A+ß+ ketosis prone diabetes.
Academic Article The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.
Academic Article Cellular metabolism constrains innate immune responses in early human ontogeny.
Academic Article Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.
Academic Article Effects of combination therapy with dipeptidyl peptidase-IV and histone deacetylase inhibitors in the non-obese diabetic mouse model of type 1 diabetes.
Academic Article Regulation of the pancreatic pro-endocrine gene neurogenin3.
Academic Article Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D.
Academic Article Transcriptional activity of the islet ß cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
Academic Article Importance of the character and configuration of residues B24, B25, and B26 in insulin-receptor interactions.
Academic Article Physicochemical characterization of bovine retinal arrestin.
Academic Article Molecular mechanisms of nonalcoholic fatty liver disease: Potential role for 12-lipoxygenase.
Academic Article Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.
Academic Article An islet in distress: ß cell failure in type 2 diabetes.
Academic Article Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications.
Academic Article Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes.
Academic Article Maintenance of Pdx1 mRNA translation in islet ß-cells during the unfolded protein response.
Academic Article Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.
Academic Article The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.
Academic Article Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.
Academic Article Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.
Academic Article Palmitate induces mRNA translation and increases ER protein load in islet ß-cells via activation of the mammalian target of rapamycin pathway.
Academic Article Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1.
Academic Article Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes.
Academic Article Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.
Academic Article Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation.
Academic Article Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.
Academic Article Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.
Academic Article The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
Academic Article Biomarkers of islet beta cell stress and death in type 1 diabetes.
Academic Article Hypusine biosynthesis in ß cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Academic Article Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes.
Academic Article Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison.
Academic Article Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention.
Academic Article Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.
Academic Article PIE-FLIM Measurements of Two Different FRET-Based Biosensor Activities in the Same Living Cells.
Academic Article Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes.
Academic Article Our Response to COVID-19 as Endocrinologists and Diabetologists.
Academic Article Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment.
Academic Article A novel Cre-enabled tetracycline-inducible transgenic system for tissue-specific cytokine expression in the zebrafish: CETI-PIC3.
Academic Article Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta-cell protection in type 1 diabetes.
Academic Article Oligomeric collagen as an encapsulation material for islet/ß-cell replacement: effect of islet source, dose, implant site, and administration format.
Academic Article The role of beta-cell dysfunction in early type 1 diabetes.
Academic Article Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.
Academic Article A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.
Academic Article Probing islet stress in type 1 diabetes.
Academic Article The demise of islet allotransplantation in the United States: A call for an urgent regulatory update.
Academic Article Hypusination Orchestrates the Antimicrobial Response of Macrophages.
Academic Article Phenotypic sexual dimorphism in response to dietary fat manipulation in C57BL/6J mice.
Academic Article Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention.
Academic Article Author Correction: Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.
Concept Firmicutes
Concept Gastrointestinal Microbiome
Concept Intravital Microscopy
Concept Endocrinologists
Concept Whole Genome Sequencing
Concept Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Concept B-Cell CLL-Lymphoma 10 Protein
Concept Janus Kinase Inhibitors
Concept Candida parapsilosis
Concept Regulatory-Associated Protein of mTOR
Concept Meals
Concept RNA, Long Noncoding
Concept Pediatric Obesity
Concept Ammonium Hydroxide
Concept Diet, Western
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